Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1208
Protein Name
Aquaporin Z
Gene Name
aqpZ; bll7116
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Length
240 amino acids
AlphaFoldDB
AF-Q89EG9-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MDMKKYAAEAIGTFWLTFAGCGSAVIAAGFPQVGIGLVGVSLAFGLSVVTMAYAIGHISGCHLNPAVTVGLAAGGRFPAGQILPYVIAQVCGAIVAAELLYIIASGAPGFDVTKGFASNGYDAHSPGQYSMMACFLTEVVMTMMFLFIIMGATHGRAPAGFAPLAIGLALVMIHLVSIPVTNTSVNPARSTGPALFVGGWAMAQLWLFWVAPLIGGALGGVIYRWLSEEPTGVVAGAKAA
PDB Structures
Ligand Binding
Binding Site
SITE 21: "Involved in tetramerization or stability of the tetramer"; SITE 44: "Selectivity filter"; SITE 174: "Selectivity filter"; SITE 183: "Selectivity filter"; SITE 189: "Selectivity filter"
Disease
Location
DOI ID
10.1093/dnares/9.6.189
RefSeq
NP_773756.1; WP_011089853.1